Celebrities on Mounjaro and Zepbound: A Sourced List

Most celebrity weight-loss-drug lists are built out of rumor and paparazzi photos. This one is not. Everyone here named a specific tirzepatide brand themselves - Mounjaro or Zepbound - in an interview, a broadcast or a post we can date and cite.

Two things to know before the list:

Mounjaro and Zepbound are the same drug. Tirzepatide, made by Eli Lilly. Mounjaro is the type 2 diabetes brand. Zepbound is the weight management brand, and since December 2024 it is also approved for moderate-to-severe obstructive sleep apnea in adults with obesity [1].

Paid and unpaid are different things. A few names here are advertising campaigns. We label those.

Which celebrities have said they use Zepbound?

Serena Williams. In August 2025 Williams said she had lost 31 pounds using Zepbound after the birth of her second child, and announced she was joining the telehealth company Ro as a paid GLP-1 celebrity patient ambassador on a multi-year campaign [2]. She fronted Ro’s first Super Bowl ad in February 2026. On the stigma, she has said the idea that a GLP-1 is a shortcut is a misconception, and that as an athlete who had done everything she simply could not get her weight where she needed it. This is a paid partnership, disclosed by Ro at the time.

Shaquille O’Neal. On June 10, 2026 O’Neal announced he takes Zepbound for moderate obstructive sleep apnea, as the face of a national Lilly awareness campaign [3]. It runs under “Watch This,” the same Zepbound platform name as the brand’s Super Bowl LX weight-loss spot four months earlier - different films, different indication, one campaign umbrella. His framing is the most unusual on this list because it is not about weight at all: “For a long time, I was tired during the day, not sleeping well at night, and I just thought that’s how it was for someone my size.” He closes with, “Talk to your doctor. That’s the play.” This is a paid Eli Lilly campaign.

Harvey Fierstein. The Broadway star said he lost about 120 pounds on Zepbound after reaching 310 pounds during the pandemic, and later regained roughly 15 pounds after stopping. His public argument has been that obesity is not a choice. Unpaid.

Kym Whitley. The comedian and actor was named one of Zepbound’s first two paid brand ambassadors in the summer of 2025, telling her own story of weight cycling in a Lilly campaign built around humor rather than before-and-after photography [4]. Lilly’s consumer marketing lead said the point was that “humor is a way to relate to people.” The company said her story generated more than 140 million impressions. Paid.

Tan France. Worth including precisely because of what he did not say. The “Queer Eye” stylist fronts Lilly’s “Changing the Thread Collection,” launched November 10, 2025, which puts stories from people living with obesity onto embroidered clothing [5]. France’s line is “So many people with obesity use clothing to hide from bias and judgment.” He is a campaign partner and has not said he uses the medicine.

Which celebrities have said they use Mounjaro?

Whoopi Goldberg. On “The View” in March 2024, the day after Oprah Winfrey’s ABC special, Goldberg said she had used Mounjaro after reaching close to 300 pounds during the filming of “Till” [6]. She has described losing the weight of “almost two people.”

Sunny Hostin. In the same episode, Hostin said she had taken Mounjaro after gaining about 40 pounds during the pandemic, and framed it medically rather than cosmetically: “I think these medications are changing lives and saving lives” [7]. She cited improved cholesterol as the reason she stayed on it, and in March 2025 spoke publicly about her experience after stopping.

Rosie O’Donnell. O’Donnell first posted about Mounjaro on TikTok in 2023 and has been consistently open since, framing it around her type 2 diabetes with weight loss as a secondary effect. She has treated the openness as a matter of principle.

Meghan Trainor. After her appearance at Billboard’s 2025 Women in Music awards drew commentary about her body rather than her career, Trainor posted that she had used Mounjaro after her second pregnancy, alongside a dietitian and a trainer.

Jim Gaffigan. The comedian, whose stage act was built on eating, told People in November 2024 that he lost 50 pounds on Mounjaro after reaching 270 pounds. In March 2026 he said he stays on it not to keep losing but to keep from regaining.

Charles Barkley. Barkley said on his CNN show that he went from about 355 pounds to roughly 285 on Mounjaro, then regained some after stopping. In April 2025 he became Ro’s first GLP-1 celebrity patient ambassador. The Ro role is paid; the original disclosure was not.

Vanessa Williams. In a January 2026 Hello! cover story, Williams said she had been taking Mounjaro for two years while managing menopause - one of a growing set of disclosures that connect tirzepatide to midlife hormonal change rather than vanity.

Eric Stonestreet. The “Modern Family” actor told People he takes Mounjaro for type 2 diabetes and had kept the diagnosis private for years out of shame. His disclosure is a useful corrective: a large share of US tirzepatide use is for diabetes.

Tori Spelling. Spelling said on her “misSPELLING” podcast that she used Mounjaro and lost about 40 pounds after the birth of her fifth child, alongside hormone therapy prescribed by her doctor [8][9]. She returned to it in April 2025, saying Mounjaro “did do the trick.”

Scott Disick. Nearly a year after viewers of “The Kardashians” spotted a box of Mounjaro in his refrigerator, Disick addressed it on the February 27, 2025 episode and refused to apologize, saying he was not embarrassed - in considerably blunter language [10]. The clip circulated widely and became one of the defining celebrity GLP-1 moments of the year.

Savannah Chrisley. The reality television personality said she stopped one GLP-1 because it flattened her enjoyment of food, switched to tirzepatide and lost about 25 pounds, then launched a company selling GLP-1 medications. Commercial interest disclosed.

Why do so many stars say Mounjaro when they mean weight loss?

Two reasons, and both trip up American readers.

Timing. Mounjaro was approved in May 2022. Zepbound did not exist until November 2023. Anyone who started early had one brand name to say.

Geography. In the United Kingdom there is no Zepbound. Tirzepatide carries the weight-management indication there under the Mounjaro name, which is why UK newspapers, UK reality stars and the NHS itself all say Mounjaro [11]. If you are reading a British interview, mentally swap in Zepbound.

Who has not named a brand?

This matters as much as the list itself.

Oprah Winfrey has never named a specific medicine. In December 2023 she told People she uses a prescription weight-loss medication as a tool, and in December 2025 she said she had stopped for about 12 months, regained roughly 20 pounds and restarted, concluding that it is “going to be a lifetime thing.” Articles that assign her a brand are guessing.

Elon Musk has named Wegovy, which is semaglutide, not tirzepatide. He belongs on a different list.

Kris Jenner, Amy Schumer, Chelsea Handler and others have discussed GLP-1s without naming a tirzepatide brand, or have named semaglutide products.

And a very large number of famous people have been the subject of speculation without saying anything at all. Those people are not on this page, and that is deliberate.

What has Eli Lilly said about celebrity use?

Something unusual for a drug company: it told celebrities to stop.

On Oscar night in March 2024, Lilly ran two films. “Big Night,” a 30-second spot on E!‘s red carpet coverage, called out people using the medicines “for a smaller dress or tux” and ended on the line that it matters who gets them. “Shame,” a one-minute film during the ABC broadcast, followed a woman through a black-and-white world of disapproving looks and closed with: “Obesity is a matter of health. Shame has no place in it” [12].

A drugmaker publicly rebuking its most fashionable customers was new. It also sat awkwardly next to what came later - by 2025 and 2026, Lilly was building campaigns around Kym Whitley, Tan France and Shaquille O’Neal. The company’s position, consistently, is that the difference is medical purpose: it wants famous people talking about obesity and sleep apnea as conditions, not about award-season dress sizes.

How should you read a celebrity disclosure?

A few honest caveats.

These are individual accounts. A number in an interview is not a trial result. Several people on this list also describe stopping, side effects or regain, and those parts of the story travel less well than the before-and-after photo.

Paid is not the same as fake, but it is different. An ambassador is being compensated to talk about a product. That does not make what they say untrue. It does mean the framing was negotiated.

Some of these disclosures are doing real work. Eric Stonestreet talking about hiding a diabetes diagnosis, Sunny Hostin talking about cholesterol, Shaquille O’Neal talking about sleep apnea - those move the conversation away from appearance, which is where most of the harm in this topic lives.

And none of it is advice. What worked for a television host with a specific medical history says nothing about what is appropriate for you. That is a conversation for a healthcare provider.

Sources

1. FDA, “FDA approves first medication for obstructive sleep apnea,” December 20, 2024. https://www.fda.gov/news-events/press-announcements/fda-approves-first-medication-obstructive-sleep-apnea
2. PR Newswire / Ro, “Serena Williams joins Ro as GLP-1 celebrity ambassador,” August 21, 2025. https://www.prnewswire.com/news-releases/serena-williams-joins-ro-as-glp-1-celebrity-ambassador-302535068.html
3. Eli Lilly, “Zepbound and Shaquille O’Neal launch national sleep apnea campaign,” June 10, 2026. https://investor.lilly.com/news-releases/news-release-details/zepbound-tirzepatide-and-shaquille-oneal-launch-national
4. Medical Marketing and Media, “Zepbound taps comedic influence from Kym Whitley in newest campaign,” August 7, 2025. https://www.mmm-online.com/news/zepbound-taps-comedic-influence-from-kym-whitley-in-newest-campaign/
5. Eli Lilly, “Queer Eye’s Tan France helps unthread obesity bias as part of Zepbound’s Changing the Thread Collection,” November 10, 2025. https://investor.lilly.com/news-releases/news-release-details/queer-eyes-tan-france-helps-unthread-obesity-bias-part-zepbounds
6. Salon, “‘The View’: Sunny Hostin and Whoopi Goldberg reveal they also used weight-loss drugs,” March 19, 2024. https://www.salon.com/2024/03/19/the-view-sunny-hostin-whoopi-goldberg-weight-loss-mounjaro/
7. AOL / People, “The View’s Whoopi Goldberg and Sunny Hostin open up about using weight-loss drugs.” https://www.aol.com/views-whoopi-goldberg-sunny-hostin-211952202.html
8. TODAY, “Tori Spelling weight loss: star talks Mounjaro, body image and more,” November 15, 2024. https://www.today.com/health/tori-spelling-weight-loss-rcna178973
9. Women’s Health, “Tori Spelling used Mounjaro to lose weight after having 5th child,” 2024. https://www.womenshealthmag.com/weight-loss/a60523992/tori-spelling-mounjaro-weight-loss/
10. Us Weekly, “Scott Disick ‘is not embarrassed’ he took Mounjaro for weight loss,” February 27, 2025. https://www.usmagazine.com/entertainment/news/scott-disick-is-not-embarrassed-he-took-mounjaro-for-weight-loss/
11. The Guardian, “NHS begins mass rollout of weight-loss jabs to patients in England,” June 23, 2025. https://www.theguardian.com/society/2025/jun/23/nhs-begins-mass-rollout-of-weight-loss-jabs-to-patients-in-england
12. Medical Marketing and Media, “Eli Lilly’s Oscars ads aim to educate on GLP-1 drugs,” March 2024. https://www.mmm-online.com/home/channel/campaigns/eli-lilly-oscars-ads-glp-1-combat-obesity-stigma/
13. The Flow Space, “Celebrities share their GLP-1 experiences,” May 19, 2026. https://www.theflowspace.com/lists/celebrities-share-glp1-drug-ozempic-wegovy-mounjaro-experiences/
14. TODAY, “Celebrities who have spoken about taking Ozempic and other GLP-1s,” updated. https://www.today.com/health/celebrities-on-ozempic-rcna129740

Nothing on this page is medical advice, and nothing here recommends a medicine or a dose. Individual accounts are not evidence of what any drug will do for anyone else. Talk to a healthcare provider.