Topic
What do the clinical trials actually show?
The trial record, endpoint by endpoint, with plain-English takeaways.
How Much Weight Do People Lose on Semaglutide? The Numbers From Every Major TrialTrial-by-trial weight-loss figures for every semaglutide dose and formulation, plus why real-world results usually land lower.How Much Weight Do People Lose on Zepbound? The Numbers From Every TrialEvery published tirzepatide weight-loss figure in one place — by dose, by population, by trial, and by how it was measured — plus what the same drug does outside of a clinical trial.SELECT Trial Explained: Semaglutide and Heart HealthThe SELECT trial followed 17,604 people with heart disease and excess weight for about four years and found semaglutide cut major cardiac events by 20% — here is what that number means and what it does not.Semaglutide Results Timeline: What Trial Data Shows Week by WeekA week-by-week map of what happened in the semaglutide trials — when appetite changes, when the scale moves, when side effects peak, and when weight loss levels off.Semaglutide vs Tirzepatide Head to Head: What SURMOUNT-5 FoundSURMOUNT-5 is the only large randomized trial that pitted tirzepatide directly against semaglutide at obesity doses — here are the numbers, the caveats, and what the trial could not measure.SURPASS-CVOT Explained: What the Big Tirzepatide Heart Trial Actually ShowedThe 13,299-person trial that tested Mounjaro against Trulicity for heart attacks, strokes and deaths — what non-inferiority means, why the mortality number comes with a caveat, and what is still unanswered.What Happens When You Stop Taking SemaglutideTrial data shows most people regain about two-thirds of lost weight within a year of stopping semaglutide, and blood pressure, cholesterol and blood sugar drift back toward baseline.What Happens When You Stop Taking Zepbound? What SURMOUNT-4 and SURMOUNT-MAINTAIN FoundThe two randomized trials that tested stopping tirzepatide — what people regained, how fast, and what happened to the group that lowered their dose instead of quitting.What the Clinical Trials Actually Show About SemaglutideA plain-English tour of the roughly 40 major semaglutide trials — what each one measured, what the numbers were, and where the evidence runs out.What the Clinical Trials Actually Show About TirzepatideA plain-English tour of the tirzepatide evidence base — the SURPASS diabetes trials, the SURMOUNT obesity trials, the heart and sleep apnea studies, what the numbers were, and where the evidence still runs out.Zepbound Results Timeline: What the Trials Show Week by WeekA week-by-week walk through what happened to trial participants on tirzepatide — from the first low dose through escalation, the steep middle stretch, the plateau, and what the three-year data shows.