Where would you like to start?

Our 218 guides are organized by the question they answer, so you can find what you need fast.

Four colored injection pens fanned out beside an open book and a small stack of documents.

By medication

By question

MedicationsWhat GLP-1 medications are approved, and at what doses?Every FDA-approved GLP-1 medication, dose by dose, explained straight from the official labels.19 guidesHow it worksHow do GLP-1 drugs actually work in the body?The science of GLP-1, GIP and the incretin drugs explained in plain English, with sources cited.11 guidesCostWhat do GLP-1s cost, and how do people pay less?What each GLP-1 costs with and without insurance, plus the ways people lower their out-of-pocket price.13 guidesInsuranceHow do you get insurance to cover a GLP-1?Prior authorization, appeals, employer and Medicaid coverage, and patient assistance, all sourced.8 guidesSide effectsHow common are GLP-1 side effects, really?How common each side effect is, what the labels warn about, and where the lawsuits stand today.13 guidesGetting startedWho qualifies for a GLP-1, and what happens first?Who qualifies, how prescriptions work, and what the first month on a GLP-1 looks like, with sources.6 guidesResultsWhat results should you expect, week by week?What to expect week by week, from plateaus to protein, exercise and everyday life on a GLP-1.9 guidesStopping and switchingWhat happens if you stop or switch GLP-1s?Weight regain evidence, maintenance dosing research, and how switching between GLP-1 drugs works.6 guidesHow to useHow do you inject, store and travel with GLP-1s?Injection technique, storage, travel, missed doses and syringe math for GLP-1 medications, all sourced.10 guidesWho they're forWho can take GLP-1s, and who should be careful?GLP-1 use by women, teens, older adults, type 1 diabetes and post-bariatric patients, with sourced guidance.7 guidesEmerging usesWhat conditions beyond weight and diabetes might GLP-1s treat?Kidney disease, heart failure, sleep apnea, Alzheimer's and other emerging GLP-1 uses, explained from sourced research.11 guidesTrial evidenceWhat do the GLP-1 trials actually show?The GLP-1 trial record, endpoint by endpoint, with plain-English takeaways drawn from the source studies.11 guidesCompoundedIs compounded semaglutide safe and legal?Compounded semaglutide and tirzepatide, telehealth providers, legality and counterfeits, covered with sourced facts.12 guidesAlternativesWhat are the alternatives to branded GLP-1s?Supplements, "natural GLP-1" claims and older prescription weight-loss drugs, compared using sourced evidence.9 guidesDrug pipelineWhat GLP-1 drugs are coming next?Sourced updates on Retatrutide, CagriSema, MariTide and every GLP-1 drug still in development.14 guidesFDA and regulationWhat are regulators doing about GLP-1s?Sourced coverage of GLP-1 approvals, shortages, label changes and enforcement in the US and abroad.9 guidesThe drugmakersWho makes Ozempic, Wegovy and Zepbound?Sourced profiles of Novo Nordisk and Eli Lilly, the two companies behind today's GLP-1 drugs.8 guidesThe GLP-1 marketHow big is the GLP-1 market?Sourced reporting on GLP-1 prescription volumes, employer and Medicaid coverage, federal policy and the patent cliff.7 guidesGLP-1 cultureHow are GLP-1s changing American life?Sourced stories on how GLP-1s are reshaping food, celebrity, work and the American economy.9 guidesCommon questionsWhat do people ask about GLP-1s?Sourced answers to the questions people actually search about semaglutide, Ozempic, Wegovy, Mounjaro and Zepbound.6 guidesNews timelineWhat has happened in the GLP-1 era?A sourced, dated record of the GLP-1 era, from the first approval to the latest headline.Timeline and year‑in‑reviewGlossaryWhat do all these words mean?Plain‑English definitions with sources.