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Which GLP-1 medications exist, and how do they differ?
Every FDA-approved GLP-1 medication, dose by dose, straight from the labels.
Bydureon and Byetta: What Happened to the First GLP-1 DrugsByetta was the first GLP-1 drug ever approved, in 2005, and Bydureon was the first weekly one, in 2012. Both were discontinued in October 2024 and the FDA withdrew their approvals in September 2025. Here is the full story and what replaced them.Every FDA-Approved GLP-1 Medication (2026 List)A complete, sourced list of every GLP-1 receptor agonist medication approved and sold in the United States as of September 2026, including what each one treats, what it costs and which ones have been discontinued.Every GLP-1 Drug Ranked by Effectiveness, Using Trial DataA ranking of the GLP-1 and incretin drugs approved in the US, built from published trial results rather than marketing claims — including which comparisons are direct head-to-head trials and which are educated guesses.Every Mounjaro and Zepbound Dose, Pen and VialTirzepatide now comes in four different devices across two brands and six strengths each. This is the complete catalog: what every dose looks like, the NDC numbers, how many doses each device holds, why the multi-dose versions use a different formulation, and how long each one lasts outside the refrigerator.How to Store and Use a Semaglutide Pen (From the Label)What the FDA-approved labels actually say about refrigerating, warming, injecting, disposing of and spotting counterfeit Ozempic and Wegovy pens.Imcivree Explained: The Obesity Drug That Is Not a GLP-1Imcivree (setmelanotide) treats rare forms of obesity caused by a broken hunger circuit in the brain, not common obesity. Here is who it is for, how it differs from Ozempic and Zepbound, what the trials showed, and what it costs.Is Trulicity Being Discontinued? What Is Actually Happening in 2026Trulicity is still on the US market as of September 2026, with no open FDA shortage record. The discontinuation rumors come from two real events that got mixed together: the exenatide brands going away in 2024, and Medicare selecting Trulicity for price negotiation in 2026.Mounjaro FAQ: The Questions People Ask GoogleWhat Mounjaro is approved for in 2026, what it costs with and without insurance, why children as young as 10 can now be prescribed it, what the new heart indication does and does not claim, how long a pen survives outside the fridge, and how to check that a box is real.Mounjaro vs Zepbound: What's the Difference?Mounjaro and Zepbound contain exactly the same drug, tirzepatide, made by the same company. What separates them is the FDA-approved use printed on the box, the devices each brand comes in, and the price you actually pay. Here is the full comparison, straight from the two labels.Ozempic vs Mounjaro: How the Two Diabetes Shots CompareOzempic and Mounjaro are both once-weekly injections for type 2 diabetes, but they are different molecules with different dosing ladders, different extra indications and different device options.Ozempic vs Wegovy vs Rybelsus: What's the Difference?Ozempic, Wegovy and Rybelsus all contain semaglutide, but they carry different FDA-approved uses, different doses and very different prices - and in 2026 Rybelsus was rebranded as the Ozempic pill.Soliqua and Xultophy: The Insulin Plus GLP-1 Combination PensTwo once-daily pens combine basal insulin with a GLP-1 drug in a fixed ratio. Here is what is in each one, who their labels cover, how they are dosed, what they cost, and why they never became popular.Switching GLP-1 Medications: What the Guidelines and Labels Actually SayThere is no FDA-approved conversion chart between different GLP-1 drugs. Here is what the labels do say about switching, what the published guidance recommends, and what happens when a discontinuation or a formulary change forces the decision for you.Trulicity vs Ozempic: What the Head-to-Head Trial Actually ShowedTrulicity and Ozempic are both once-weekly GLP-1 injections for type 2 diabetes, and they were compared directly in a 1,201-person trial. Here is what that trial found, how the two drugs differ on dosing, devices, price and heart benefits, and what is changing in 2026.Wegovy Pill: Everything We KnowThe Wegovy pill is FDA-approved oral semaglutide 25 mg for weight management - here is what the label says about doses, how to take it, how much weight people lost in trials, and what it costs.Wegovy vs Zepbound: Which Weight-Loss Shot Does What?Wegovy and Zepbound are the two leading FDA-approved weekly injections for weight management - they use different molecules, carry different extra indications, come in different devices and are priced very differently.Zepbound FAQ: The Questions People Ask GoogleWhat Zepbound treats, which doses the label calls maintenance doses and which it does not, how much weight people lost in the trials, what it costs on every payment route, why the suicidality warning disappeared in 2026, and the storage and sharing rules that come with the new KwikPen.Zepbound for Sleep Apnea: What the Approval MeansIn December 2024 Zepbound became the first prescription medicine ever approved for obstructive sleep apnea. This explains exactly who the approval covers, what the trials showed, why the label uses higher maintenance doses than it does for weight, and the one sentence in the label that everyone hoping to ditch their CPAP should read.Zepbound Vials Explained: LillyDirect, Prices and How They WorkZepbound single-dose vials are the cheapest way to buy brand-name tirzepatide in the United States, but they only exist inside one channel and the price depends on a 45-day refill rule most people miss. Here is how the vials work, what they cost, how the price got here, and what you have to buy separately.