Celebrities describe using semaglutide and tirzepatide, from 52 pounds lost to treatment stopped

Celebrities are increasingly willing to say publicly that they use GLP-1 medications, and their accounts describe a wide range of results, from 52 pounds lost to a psychiatric side effect serious enough to stop treatment ^[1]. The disclosures have arrived as the drugs' popularity grew and as the public speculated about which stars were using them ^[1].

Ozempic is approved to treat Type 2 diabetes, and weight loss is a prominent side effect, so it is often prescribed off-label for that purpose, according to TODAY.com ^[1]. Its active ingredient, semaglutide, is also approved to treat obesity under the brand name Wegovy ^[1]. Novo Nordisk, which makes Ozempic and Wegovy, has said it does not support off-label use of its medications ^[1]. Mounjaro is approved for diabetes and Zepbound for obesity; both are made by Eli Lilly and contain tirzepatide ^[1].

What celebrities have said

Renee Graziano of "Mob Wives" posted a before-and-after photo on Instagram and said she had lost 52 pounds by May 2025 using Mounjaro ^[1]. Savannah Chrisley said she stopped her first weight-loss drug because she did not like the way it manipulated her appetite, then switched to a different drug and lost 25 pounds. "I love tirzepatide," she said on her podcast, adding that it did not give her the side effects other drugs gave her ^[1]. Her company, Good Girl RX, now sells GLP-1 medications ^[1].

Vanessa Williams began taking Mounjaro while going through menopause, saying she wanted to look her best at 60. "It's a game-changer," she told Hello! Magazine ^[1]. Rosie O'Donnell said in August 2025 that she now wears a size 12 and called Mounjaro "a life saver" ^[1]. Meghan Trainor said she used Mounjaro after her second pregnancy along with a dietitian and a trainer ^[1]. Serena Williams used a GLP-1 after the birth of her second child; she told TODAY.com that her blood sugar levels improved and her joints feel lighter ^[1]. Eric Stonestreet has taken Mounjaro for his Type 2 diabetes since before the drug's May 2022 launch ^[1].

Other accounts were less positive. Bunnie XO said in December 2025 that she had "a bout of suicidal ideation" while taking a GLP-1, describing it as one of the darkest times of her life ^[1]. She said both of her parents had diabetes and that her body "cannot tolerate" the drug ^[1]. Chrissy Teigen said she turned to Ozempic after a 2020 miscarriage, when she had gained about 40 pounds, and that the reduction in hunger cues was frustrating for her ^[1]. Kelly Clarkson said she takes a weight-loss drug she did not name: "Everyone thinks it's Ozempic — it's not. It's something else" ^[1]. She said her heaviest weight was 203 pounds ^[1]. Oprah Winfrey said in December 2023 that she uses a weight-loss drug but did not specify which one ^[1].

The full details of comedian Amy Schumer's remarks about the drugs, including what she has said about her own experience with Ozempic, have not been reported in the celebrity accounts compiled by TODAY.com ^[1].

Why it matters for patients

The accounts show that the same class of medications produces very different experiences. Some people in these reports lost 25 to 52 pounds; others stopped treatment because of side effects, and one described suicidal thoughts while taking a GLP-1 ^[1].

Approval status also differs by product. Ozempic and Mounjaro are approved for Type 2 diabetes, while Wegovy and Zepbound are approved for obesity ^[1]. Doctors can prescribe a drug off-label, but Novo Nordisk has said it does not support off-label use of its medications ^[1].

Several people in these reports did not name the specific drug they used, and the doses and treatment lengths behind each result have not been disclosed ^[1]. How often serious side effects such as suicidal ideation occur with these medications is not established by these individual accounts ^[1].