Bunnie XO says she had suicidal ideation while taking a GLP-1

Bunnie XO, the podcast host and wife of musician Jelly Roll, said she went through "a bout of suicidal ideation" while taking a GLP-1 medication, an experience she described in a December 2025 interview ^[1]. Her account is one of the most widely circulated disclosures of a serious psychiatric symptom connected to the drug class that includes Ozempic, Wegovy, Mounjaro and Zepbound ^[1].

Bunnie XO said she had not dealt with depression before. "I prided myself on the fact that I only had anxiety," she said. "I never had depression. So when you get slammed with suicidal ideation and visions and just, oh, it was horrific." ^[1]

She said she tried the drug because diabetes runs in her family. "Both my parents had diabetes," she said. "So my insulin numbers are really crazy and my body just cannot tolerate it." ^[1] She described that time as a "rough month" and said she is "good now" ^[1].

The specific medication she took has not been disclosed, and neither have the dose or how long she stayed on it ^[1]. The account does not say whether she or her doctors reported the reaction to the Food and Drug Administration or to a manufacturer, and it includes no response from any drugmaker ^[1].

For context on the drug class: Ozempic is approved to treat type 2 diabetes and is often prescribed off-label for weight loss because weight loss is a prominent side effect. The same active ingredient, semaglutide, is approved to treat obesity under the name Wegovy, made by Novo Nordisk. The company has told TODAY.com that it does not support off-label use of its medications. Mounjaro is approved for diabetes and Zepbound for obesity; both are made by Eli Lilly ^[1].

Most celebrity disclosures in the same roundup describe benefits or mixed experiences. Renee Graziano said she had lost 52 pounds on Mounjaro as of May 2025. Savannah Chrisley said she lost 25 pounds and said, "I love tirzepatide." Eric Stonestreet takes Mounjaro for his type 2 diabetes and calls it "a game changer." Rosie O'Donnell has posted about Mounjaro, writing that she was shocked to be a size 12. Meghan Trainor credited Mounjaro after her second pregnancy, Chrissy Teigen used Ozempic after a miscarriage, and Serena Williams used a GLP-1 after the birth of her second child ^[1].

Why it matters for patients

Public discussion of these medications tends to focus on weight loss, appetite and cost. Bunnie XO's account puts a psychiatric symptom into that conversation, from a person with a large audience who says she took the drug partly because of a family history of diabetes ^[1].

Several things about her case are not established. The account does not say which GLP-1 she used, so it is not known whether the drug was semaglutide, tirzepatide or another medicine in the class ^[1]. Nothing in the material shows a cause-and-effect link between the drug and her symptoms, and no rate or frequency for this kind of reaction is given ^[1]. It is also not known whether any regulator or manufacturer has reviewed or responded to her account ^[1].

For patients, the practical takeaway is mainly about information: this is a reported first-person experience, not a finding about how often such symptoms occur. People who take these drugs, and the family members and friends around them, now have one more public account to weigh alongside the more common reports of weight loss and improved blood sugar ^[1]. No change to prescribing labels, guidance or approved uses has been reported as a result of her comments ^[1].

What happens next

Bunnie XO says she is "good now," and the interview does not say whether she stopped the medication, switched to another drug or continued taking it ^[1]. No follow-up timeline beyond her December 2025 comments has been reported ^[1].

Neither Novo Nordisk nor Eli Lilly is quoted responding to her account, and no statement from the FDA about it has been reported ^[1]. Whether either company or the agency addresses it later has not been disclosed ^[1].