Rosie O'Donnell posts about Mounjaro on TikTok

In March 2023, Rosie O'Donnell began posting about her experience with Mounjaro (tirzepatide) on TikTok, sharing weight updates that she continued for three years, according to the development summary. This made her one of the first entertainers to narrate a GLP-1 drug experience openly and repeatedly on social media, rather than through a single interview or a brief public statement.

Available reporting on celebrity GLP-1 disclosures does not include specific details about O'Donnell's posts, so the exact numbers, dates, or wording of her TikTok updates are not yet known from the sources reviewed for this story. What is documented is the wider trend she was part of: a growing list of well-known figures who have talked publicly about taking semaglutide or tirzepatide drugs, often years after they started ^[1].

That pattern includes actor Whoopi Goldberg, who told cohosts on "The View" in 2024 that she used Mounjaro to lose weight after her role in the 2022 film "Till," saying she weighed almost 300 pounds at the time ^[1]. Former NBA star Charles Barkley said on "The Pat McAfee Show" that he lost around 60 pounds on Mounjaro, going from 352 pounds down to 290, with a goal of 270, while also exercising and eating differently ^[1]. Comedian Jim Gaffigan told People in 2024 that he lost 50 pounds on Mounjaro after his weight reached 270 pounds, and later said in 2026 that he kept using the drug even without further weight loss because it curbed his appetite ^[1]. Singer Meghan Trainor posted on Instagram in 2025 that she and her husband used the lowest dose of a GLP-1 medication, naming Mounjaro specifically, alongside a dietitian, exercise, and lifestyle changes after her second pregnancy ^[1].

Other celebrities have described using different brands or for different reasons. Oprah Winfrey discussed her GLP-1 use on an ABC special in March 2024 and later told People in December 2025 that she regained about 20 pounds after stopping the medication for a year to test whether she could keep weight off without it, concluding it would be "a lifetime thing" for her, similar to blood pressure medication ^[1]. Shaquille O'Neal said in June 2026 that he takes Zepbound (tirzepatide) for obstructive sleep apnea, not primarily for weight loss, and that the drug helped his sleep condition while he also lost some weight ^[1].

Why it matters for patients

When entertainers post regularly about their own GLP-1 use, it can shape how the public understands these drugs, sometimes more than a single medical study or FDA notice. O'Donnell's three years of updates would have overlapped with a period when Mounjaro was approved only for type 2 diabetes and its sibling drug Zepbound had not yet reached the market, and when public understanding of side effects, cost, and long-term use was still developing.

Celebrity accounts like the ones documented in available sources show a range of outcomes: some people report sustained weight loss with lifestyle changes, some report regaining weight after stopping the drug, and some use it for a specific condition rather than weight loss alone ^[1]. These accounts are personal experiences, not clinical evidence, and they vary widely in dose, duration, and reason for use.

What happens next

The original TikTok posts from O'Donnell that reportedly ran from March 2023 through 2026 are not detailed in the sources available for this story, so further verification of specific claims, dates, or quotes from those posts is not yet possible from this reporting.