Sharon Osbourne warns about Ozempic after dropping below 100 pounds

Sharon Osbourne, then 71, told the Daily Mail in an interview published Nov. 17, 2023 that she had lost about 42 pounds on Ozempic, had dropped below 100 pounds, and could not put weight back on. "Be careful what you wish for," she said. "My warning is don't give it to teenagers, it's just too easy." ^[2][1]

Osbourne said she started the drug in December 2022 and stopped after roughly a year because she "couldn't stop losing weight." ^[1][2] "I'm too gaunt and I can't put any weight on," she told the outlet. "I want to, because I feel I'm too skinny. I'm under 100 pounds and I don't want to be." She added that she "can't afford to lose any more." ^[2][1]

The numbers she has given have shifted slightly across interviews. Most accounts, including the November 2023 one, put the loss at 42 pounds ^[1][2]; a January 2024 E! write-up of her appearance on the U.K. show Loose Women described it as 40 pounds ^[2]. In February 2024 she told The Guardian she lost "three stone [42 pounds] in four months. Too much." ^[1] In a September 2023 E! interview she said her heaviest weight had been 230 pounds and that she wanted to settle around 105 because she was "too skinny." ^[1]

What she said about side effects and stopping

On Bill Maher's "Club Random" podcast in August 2023, Osbourne described the early weeks bluntly: "You just throw up all the time and feel so nauseous," she said, adding that after a couple of weeks the nausea faded and she felt "fine, just not hungry." ^[1]

Stopping did not bring the weight back, by her account. On Good Morning Britain in December 2023 she said, "I could do with putting on a few pounds, but at this point the way my body is, it's not listening." ^[1] On Loose Women on Jan. 15, 2024, she said she did not regret taking it: "The injections that I was on worked, and it just seems that now I can't put anything on... If I could, I'd put back another 10 [pounds]." ^[2] Later, on a podcast with Howie Mandel, she said, "I can't put on weight now, and I don't know what it's done to my metabolism, but I just can't seem to put any on, because I think I went too far." ^[1]

Why it matters for patients

This is one person's self-report, not a study. The sources do not say what dose she used, who prescribed it, whether she was monitored, or whether any medical evaluation explained why her weight stayed low after stopping. Those details are not known from the available reporting.

Still, two things in her account are worth understanding accurately. First, Ozempic is semaglutide approved by the FDA to lower blood sugar in adults with type 2 diabetes, alongside diet and exercise, and to reduce the risk of heart attack, stroke, or death in adults with type 2 diabetes and known heart disease ^[1]. Osbourne described using it for weight loss. Second, she framed the risk as losing more weight than intended and struggling to reverse it — a different worry than the nausea and vomiting that dominate most side-effect conversations, and one she attributed partly to her own "I want it now" approach to weight ^[2][1].

Her specific warning about teenagers — "it's just too easy" and "easy to become addicted to" rapid loss — is her opinion ^[1][2]. The sources provided do not include any clinical data on GLP-1 use in adolescents, how these drugs are regulated for that age group, or whether doctors share her concern. That gap is real, and readers should not read her statement as a regulatory or scientific finding.

Osbourne has said she does not regret it, and that she is "through with the weight loss and all that cosmetic stuff." ^[1][2] Her case became a reference point in celebrity GLP-1 coverage mainly because it cut against the promotional tone of most of it.