Chrissy Teigen says she used Ozempic after her 2020 pregnancy loss

In September 2025, Chrissy Teigen said she used Ozempic following her 2020 pregnancy loss, describing the decision on an episode of her podcast Self-Conscious ^[1].

Teigen said she lost a baby at 20 weeks. She had gained weight during the pregnancy — she put the figure at about 40 pounds she "wasn't comfortable with" — and afterward it would not come off. "My body was completely stuck," she said, describing that period as a "deep depression" over "this pregnant belly with no baby in it" ^[1].

One other part of the experience stood out to her: hunger signals fading. "It was frustrating for me because I know that logically you need food to have energy," she said ^[1].

Ozempic is a brand name for semaglutide and is approved to treat type 2 diabetes. Weight loss is a prominent side effect, and the drug is often prescribed off-label for that reason. The same molecule is approved to treat obesity under the name Wegovy. Novo Nordisk, which makes both, has said it does not support off-label use of its medicines ^[1]. Eli Lilly sells two comparable products: Mounjaro (tirzepatide), approved for diabetes, and Zepbound (tirzepatide), approved for obesity ^[1].

For obesity, semaglutide produced average weight loss of about 12.7 kilograms — nearly 28 pounds — over 68 weeks compared with a placebo ^[2]. Among people with type 2 diabetes, GLP-1 drugs can lower HbA1c, a blood sugar marker, by roughly 0.9% within six months, alongside about 3.3 pounds of weight loss in that period, according to data published in JAMA Internal Medicine ^[2]. The drugs have also been shown to reduce the risk of major cardiovascular events such as heart attacks and strokes in patients with type 2 diabetes, regardless of their effect on blood sugar ^[2].

Teigen has not said what dose she took, how long she stayed on Ozempic, whether she still takes it, or what condition it was prescribed for ^[1].

Why it matters for patients

Blunting appetite is how these medicines work, not an unintended flaw, which means that eating too little is a practical part of treatment for some people. Teigen's description of knowing she needed food without feeling hungry ^[1] is one account of that, and it lines up with what others in this drug class have reported ^[1].

Weight gained during a pregnancy that ends in loss is not an approved use for any GLP-1 medication. Teigen's account does not say the drug was given to treat grief or depression, and whether these medicines affect mood has not been established ^[1]. Podcast host Bunnie XO has said she went through "a bout of suicidal ideation" while taking a GLP-1, and she told People she is "good now" ^[1].

The public conversation around these drugs mixes very different outcomes. Some celebrities describe better blood sugar and joints that feel lighter; others describe side effects they could not tolerate ^[1]. Those are individual stories, and they do not establish what a typical patient should expect ^[1].